LDV Vans Trophy holders Blackpool were dumped out of this season's competition after conceding two second-half goals at Crewe.
Teenage striker Dean Ashton hit his first goal for the Railwaymen since March 27 and Rodney Jack added the second in a 2-0 victory.
Ashton making a rare start, had first-half chances to break the deadlock before he seized on Chris Clarke's weak clearing header from a long goal-kick by Ade Bankole and drilled a low shot past Phil Barnes.
He was involved in Crewe's second, when Barnes could only block his effort inside the box and Jack finished off the rebound