Crewe's first away game is a trip to Blundell Park and Grimsby followed with another away game when the Alex make their first appearance at Darlington's new stadium.
Other key games see a Cheshire derby against Macclesfield on 5th Sept with the return fixture on 28th December.
The eagerly awaited game against near neighbours Port Vale takes place on 17th October at Gresty Road with the return on 27th March.
Trips to the seaside see the Railwaymen travel to Bournemouth on the August Bank Holiday weekend while a trip to Torquay comes in March and Morecambe over Easter weekend.
Other key dates see Crewe at home to Rochdale on Boxing Day while the last away game of the season sees Crewe travelling to Rotherham while the last game of the season is a home game against Bradford City.