Club captain Lowe picked up a hamstring injury in the 2-1 away defeat against Cambridge United but he could be fit for the New Years Eve clash against Accrington Stanley.
With Lowe ruled out it could mean a start for Daneil Udoh who featured and netted in the 4-3 win over Barnsley U23 game.
Defender Ben Nugent picked up a cheekbone injury in the clubs U23 game against Barnsley on Wednesday and is ruled out, while Callum Saunders is not fully fit but could be in contention for the away game at Morcambe.
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