Rodney Jack and Michael Higdon will not be risked to the long trip to the capital as Crewe look to get back to winning ways.
Jack has a slight knee strain while Higdon has a slight ankle injury both could be used at some point over the festive period.
Dario told the official Crewe site'"Rodney has tweaked his knee and we won't risk him. If it had been the last game of the season and a vital match, then we probably would have but it's not and we have sufficient cover there.
"It is nothing serious and we expect to have him for for Boxing Day. We will also be without Michael Higdon. He has been carrying a slight ankle injury, so he won't be travelling this afternoon."
Crewe will hope to take three points from the O's who have seemed to have found some form, with back to back wins over Nottingham Forest (4-1) and Northampton Town (1-0).
Probable team.
Tomlinson
Baudet
Cox
Jones
Otsemobor
Vaughan
Rix
Roberts
O'Connor
Varney
Matthews
Subs
Williams
Maynard
O'Donnell
Moss
Grant