Ashton United who overcame Woodley Sports in the Third round qualifier to set up the tie with the Railwaymen.
Last season the Railwaymen went out at the third round to Cambridge United at the Abbey Stadium last season and will hope to carry on their fine form in the U-18 league in the cup.
The Railwaymen made the last four back in 2004 when they lost 3-0 over the two legs to Middlesborough. Of that night only Owain fon Williams, Roberts, O'Connor, Maynard and Carrington are still at the club.